信號(hào)轉(zhuǎn)導(dǎo)因子和轉(zhuǎn)錄激活因子3 (phospho Tyr705)多克隆抗體

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產(chǎn)品英文名稱	Stat3 (phospho Tyr705) Polyclonal Antibody
免疫原	合成多肽：人源蛋白Stat3，磷酸化多肽，中心氨基酸為Y705.
宿主	兔
反應(yīng)性	人, 大鼠, 小鼠
應(yīng)用	ELISA, IF, IHC-P, IP, WB
實(shí)驗(yàn)建議	最佳的工作稀釋比例需要客戶摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，IHC-p：1:100-1:300。 IP：2-5 ug/mg lysate。 ELISA：1:20000。尚未在其他應(yīng)用中測試。
克隆性	多克隆
純化工藝	使用表位特異性的免疫原，通過親和層析，從兔抗血清中親和純化抗體。

產(chǎn)品形式	液體溶液
濃度	1 mg/ml
儲(chǔ)存緩沖液	含有50％甘油，0.5％BSA和0.02％疊氮化鈉的PBS緩沖液。
保存建議	自發(fā)貨之日起，-20°C可穩(wěn)定保存1年。為最大限度的避免損失，請?jiān)诖蜷_管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復(fù)凍融。
運(yùn)輸條件	藍(lán)冰運(yùn)輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何專利或許可證。對于使用本產(chǎn)品可能發(fā)生的專利侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

背景	Signal transducer and activator of transcription 3 encoded by STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Signal transducer and activator of transcription 3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Signal transducer and activator of transcription 3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in STAT3 are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
基因ID	6774
別名	STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
其它	該抗體可檢測內(nèi)源蛋白
蛋白質(zhì)ID	P40763
目標(biāo)條帶分子量（KD)	88